chat — re: CELL-2849

#miocene #appendix #gabriel #raphael #uriel #chat #prefiling #galt

re: CELL-2849 — Vermiform appendix: flagged for deprecation

# miocene Gabriel, Raphael, Uriel

Gabriel ~10 Mya #

Doing a build review of the hominid primate digestive architecture. The vermiform appendix is present at the ileocecal junction in every lineage we have shipped. It is not in the body plan specification. It is not in the digestive system roadmap. It is not in IMMUNO-0001. Has anyone documented what this structure is supposed to be doing?

Raphael ~10 Mya #

I've looked at this one. The lymphoid follicle architecture is actually quite elegant — dense germinal centers, substantial IgA output, a clean vascular tree off the ileocolic artery. Someone put thought into this. I would not call it vestigial without more evidence.

Gabriel ~10 Mya #

Raphael. The Peyer's patches in the ileum do this. The Peyer's patches are in IMMUNO-0001.

Raphael ~10 Mya #

the peyer's patches are in the ileum. this is at the cecum. that is a different location.

Gabriel ~10 Mya #

The location is not the question. What is the appendix contributing, specifically, that IMMUNO-0001's ileal coverage does not already provide? That is the question. I need it answered before I can update the specification.

Raphael ~10 Mya #

I'll find it.

Gabriel ~10 Mya #

Filing this.→ CELL-2849

Uriel ~10 Mya #

Marked P3. No status change.

Raphael did not find it. The ticket spent 9.7 million years at P3.